Abstract
Hyphenation with liquid chromatography has become indispensable in mass spectrometry-based proteomics. Sample complexity together with the large variations in dynamic range can be only tackled using techniques that isolate and/or concentrate individual components prior to mass spectrometric analysis. In this review the most recent developments in micro/nanoliquid chromatography interfaced with MALDI and electrospray ionisation are discussed. Particular attention is focused on all applications related to quantitative proteomics.
Keywords: Liquid Chromatography, Mass Spectrometry, proteomics, MALDI, electrospray ionisation
Combinatorial Chemistry & High Throughput Screening
Title: Offline and Online Liquid Chromatography Mass Spectrometry in Quantitative Proteomics
Volume: 12 Issue: 2
Author(s): Jessica Z. Bereszczak and Francesco L. Brancia
Affiliation:
Keywords: Liquid Chromatography, Mass Spectrometry, proteomics, MALDI, electrospray ionisation
Abstract: Hyphenation with liquid chromatography has become indispensable in mass spectrometry-based proteomics. Sample complexity together with the large variations in dynamic range can be only tackled using techniques that isolate and/or concentrate individual components prior to mass spectrometric analysis. In this review the most recent developments in micro/nanoliquid chromatography interfaced with MALDI and electrospray ionisation are discussed. Particular attention is focused on all applications related to quantitative proteomics.
Export Options
About this article
Cite this article as:
Bereszczak Z. Jessica and Brancia L. Francesco, Offline and Online Liquid Chromatography Mass Spectrometry in Quantitative Proteomics, Combinatorial Chemistry & High Throughput Screening 2009; 12 (2) . https://dx.doi.org/10.2174/138620709787315418
DOI https://dx.doi.org/10.2174/138620709787315418 |
Print ISSN 1386-2073 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5402 |
Call for Papers in Thematic Issues
Artificial Intelligence Methods for Biomedical, Biochemical and Bioinformatics Problems
Recently, a large number of technologies based on artificial intelligence have been developed and applied to solve a diverse range of problems in the areas of biomedical, biochemical and bioinformatics problems. By utilizing powerful computing resources and massive amounts of data, methods based on artificial intelligence can significantly improve the ...read more
Eco-friendly Agents for Biological Control of Pathogenic Diseases
The discovery of an alternative biological approach to disease management includes work on medicinal products derived from natural sources as a starting point for the development of eco-friendly agents for these diseases and the injuries they cause, as well as reducing human contact with hazardous chemicals and their residues. We ...read more
Emerging trends in diseases mechanisms, noble drug targets and therapeutic strategies: focus on immunological and inflammatory disorders
Recently infectious and inflammatory diseases have been a key concern worldwide due to tremendous morbidity and mortality world Wide. Recent, nCOVID-9 pandemic is a good example for the emerging infectious disease outbreak. The world is facing many emerging and re-emerging diseases out breaks at present however, there is huge lack ...read more
Exploring Spectral Graph Theory in Combinatorial Chemistry
Scope of the Thematic Issue: Combinatorial chemistry involves the synthesis and analysis of a large number of diverse compounds simultaneously. Traditional methods rely on brute force experimentation, which can be time-consuming and resource-intensive. Spectral Graph Theory, a branch of mathematics dealing with the properties of graphs in relation to the ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Immuno-Informatics Quest against COVID-19/SARS-COV-2: Determining Putative T-Cell Epitopes for Vaccine Prediction
Infectious Disorders - Drug Targets Innate Immunity and Microbes: Conversations with the Gut Leading to Intestinal Tissue Repair and Fibrosis
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Comparison of QSARs and Characterization of Structural Basis of Bioactivity Using Partial Order Theory and Formal Concept Analysis: A Case Study with Mutagenicity
Current Computer-Aided Drug Design Nosocomial Infections In Paediatrics: Simple Preventive Measures, Great Results
Current Pediatric Reviews Post-Discharge Prophylactic Anticoagulation in COVID-19 Patients: A Clinical Dilemma
Cardiovascular & Hematological Disorders-Drug Targets NMDA Receptors are not Alone: Dynamic Regulation of NMDA Receptor Structure and Function by Neuregulins and Transient Cholesterol-Rich Membrane Domains Leads to Disease-Specific Nuances of Glutamate- Signalling
Current Topics in Medicinal Chemistry Fungal Infections in COVID-19-Positive Patients: A Lack of Optimal Treatment Options
Current Topics in Medicinal Chemistry Synthesis of 1H-1,2,3-triazoles and Study of their Antifungal and Cytotoxicity Activities
Medicinal Chemistry Emerging Hsp90 Inhibitors: From Discovery to Clinic
Anti-Cancer Agents in Medicinal Chemistry Phytochemicals as Potential Curative Agents against Viral Infection: A Review
Current Organic Chemistry Isomannide and Derivatives. Chemical and Pharmaceutical Applications
Mini-Reviews in Organic Chemistry Coumarins: Auspicious Cholinesterase and Monoamine Oxidase Inhibitors
Current Topics in Medicinal Chemistry Antiviral Activity of Bee Products
Current Pharmaceutical Design Good Uptake of the COVID-19 Vaccine among Patients with Rheumatic Diseases in the United Arab Emirates (UAE)
New Emirates Medical Journal Tubulin-Targeting Agents in Hybrid Drugs
Current Medicinal Chemistry Repurposing Ruxolitinib in Combating COVID-19: A Mini-review
New Emirates Medical Journal Developments of Indoles as Anti-HIV-1 Inhibitors
Current Pharmaceutical Design Directing Cardiomyogenic Differentiation and Transdifferentiation By Ectopic Gene Expression – Direct Transition Or Reprogramming Detour?
Current Gene Therapy COVID-19-associated Coagulopathy: Role of Vitamins D and K
Current Pharmaceutical Biotechnology Advances in Chromatographic Analyses of Fluoroquinolones in Pharmaceuticals and Biological Samples - A Review Article
Current Pharmaceutical Analysis