Avoiding volatile and toxic organic solvents during each particular phase of synthetic protocols should become important goal of chemical synthesis designers in academia and particularly in the industrial research community. Solvent- free reaction conditions (SFRC) are becoming a widely used experimental technique for the selective and efficient introduction of halogen atoms into organic compounds. The different approaches to the preparation of halosubstituted organic molecules using equimolar amount of the substrate and reagent under SFRC are reviewed and evaluated. Fluorination of various types of organic compounds under SFRC using fluorine gas, N-F reagents, and hydrogen or metal fluorides is compiled. Chloro-, bromo- or iodofunctionalisation under SFRC using molecular halogens, N-halosuccinimides, hydrogen or others halides is reviewed. Oxidative halogenations of comprehensive types of organic compounds under SFRC are evaluated.
Keywords: Solvent- free reaction conditions (SFRC), halogen atoms, organic compounds, Fluorination, N-halosuccinimides
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