PDGF-D Signaling: A Novel Target in Cancer Therapy

Author(s): Zhiwei Wang, Dejuan Kong, Yiwei Li, Fazlul H. Sarkar.

Journal Name: Current Drug Targets

Volume 10 , Issue 1 , 2009

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Abstract:

Platelet-derived growth factor-D (PDGF-D) is a newly recognized growth factor that can regulate many cellular processes, including cell proliferation, transformation, invasion, and angiogenesis by specifically binding to and activating its cognate receptor PDGFR-β. The functions of PDGF-D in human cancer progression are largely unknown. We discuss here the role of PDGF-D signaling pathway in cancer and how its deregulation is involved in tumor development and progression to metastatic disease.

Keywords: PDGF-D, cancer, EMT, signaling, therapy, invasion, stem cells, nutrition

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Article Details

VOLUME: 10
ISSUE: 1
Year: 2009
Page: [38 - 41]
Pages: 4
DOI: 10.2174/138945009787122914

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