Abstract
Platelet-derived growth factor-D (PDGF-D) is a newly recognized growth factor that can regulate many cellular processes, including cell proliferation, transformation, invasion, and angiogenesis by specifically binding to and activating its cognate receptor PDGFR-β. The functions of PDGF-D in human cancer progression are largely unknown. We discuss here the role of PDGF-D signaling pathway in cancer and how its deregulation is involved in tumor development and progression to metastatic disease.
Keywords: PDGF-D, cancer, EMT, signaling, therapy, invasion, stem cells, nutrition
Current Drug Targets
Title: PDGF-D Signaling: A Novel Target in Cancer Therapy
Volume: 10 Issue: 1
Author(s): Zhiwei Wang, Dejuan Kong, Yiwei Li and Fazlul H. Sarkar
Affiliation:
Keywords: PDGF-D, cancer, EMT, signaling, therapy, invasion, stem cells, nutrition
Abstract: Platelet-derived growth factor-D (PDGF-D) is a newly recognized growth factor that can regulate many cellular processes, including cell proliferation, transformation, invasion, and angiogenesis by specifically binding to and activating its cognate receptor PDGFR-β. The functions of PDGF-D in human cancer progression are largely unknown. We discuss here the role of PDGF-D signaling pathway in cancer and how its deregulation is involved in tumor development and progression to metastatic disease.
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Cite this article as:
Wang Zhiwei, Kong Dejuan, Li Yiwei and Sarkar H. Fazlul, PDGF-D Signaling: A Novel Target in Cancer Therapy, Current Drug Targets 2009; 10 (1) . https://dx.doi.org/10.2174/138945009787122914
DOI https://dx.doi.org/10.2174/138945009787122914 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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