Chemoenzymatic Synthesis of Small Molecule Human Therapeutics

Author(s): Ningqing Ran, Eugene Rui, Jinhua Liu, Junhua Tao.

Journal Name: Current Pharmaceutical Design

Volume 15 , Issue 2 , 2009

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Pharmaceuticals have historically been produced by either chemical synthesis or whole cell fermentation. The former is applied to synthetic small molecules while the latter to natural products. As a result of recent advances in rapid discovery of enzymes through genome mining and metagenomics, and their tunability in functions and stability through directed evolution, biocatalysis is emerging to be a transformational technology for drug discovery and production. Enzymes can catalyze reactions otherwise challenging by chemical approaches. Furthermore, enzymatic catalysis is a powerful tool for green chemistry development. This manuscript gives a brief overview of current status in integrating chemical and biological transformations for the synthesis of small molecular therapeutics.

Keywords: Biocatalysis, chemoenzymatic synthesis, antibiotics, anticancer agents, antidepressants, anti-cholesterol agents, anticonvulsants

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Article Details

Year: 2009
Page: [134 - 152]
Pages: 19
DOI: 10.2174/138161209787002924
Price: $58

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