Abstract
Pharmaceuticals have historically been produced by either chemical synthesis or whole cell fermentation. The former is applied to synthetic small molecules while the latter to natural products. As a result of recent advances in rapid discovery of enzymes through genome mining and metagenomics, and their tunability in functions and stability through directed evolution, biocatalysis is emerging to be a transformational technology for drug discovery and production. Enzymes can catalyze reactions otherwise challenging by chemical approaches. Furthermore, enzymatic catalysis is a powerful tool for green chemistry development. This manuscript gives a brief overview of current status in integrating chemical and biological transformations for the synthesis of small molecular therapeutics.
Keywords: Biocatalysis, chemoenzymatic synthesis, antibiotics, anticancer agents, antidepressants, anti-cholesterol agents, anticonvulsants
Current Pharmaceutical Design
Title: Chemoenzymatic Synthesis of Small Molecule Human Therapeutics
Volume: 15 Issue: 2
Author(s): Ningqing Ran, Eugene Rui, Jinhua Liu and Junhua Tao
Affiliation:
Keywords: Biocatalysis, chemoenzymatic synthesis, antibiotics, anticancer agents, antidepressants, anti-cholesterol agents, anticonvulsants
Abstract: Pharmaceuticals have historically been produced by either chemical synthesis or whole cell fermentation. The former is applied to synthetic small molecules while the latter to natural products. As a result of recent advances in rapid discovery of enzymes through genome mining and metagenomics, and their tunability in functions and stability through directed evolution, biocatalysis is emerging to be a transformational technology for drug discovery and production. Enzymes can catalyze reactions otherwise challenging by chemical approaches. Furthermore, enzymatic catalysis is a powerful tool for green chemistry development. This manuscript gives a brief overview of current status in integrating chemical and biological transformations for the synthesis of small molecular therapeutics.
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Cite this article as:
Ran Ningqing, Rui Eugene, Liu Jinhua and Tao Junhua, Chemoenzymatic Synthesis of Small Molecule Human Therapeutics, Current Pharmaceutical Design 2009; 15 (2) . https://dx.doi.org/10.2174/138161209787002924
DOI https://dx.doi.org/10.2174/138161209787002924 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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