Protein Crystallography in Drug Discovery

Author(s): Fernanda Canduri , Walter Filgueira de Azevedo Jr. .

Journal Name: Current Drug Targets

Volume 9 , Issue 12 , 2008

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Abstract:

Protein crystallography is the main technique used to obtain three-dimensional information for binary complexes involving protein and drugs. Once a protein target has its three-dimensional structure elucidated, the next natural step is the solving of the structure complexed either with its natural substrate, or any ligand or even an inhibitor. Such information is of pivotal importance to understand the structural basis for inhibition of an enzyme. The relevant features, for application of protein crystallography to drug discovery, are discussed in this review.

Keywords: Protein, Crystallography, Drug Discovery, three-dimensional structure, natural substrate, ligand, enzyme, inhibitor

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Article Details

VOLUME: 9
ISSUE: 12
Year: 2008
Page: [1048 - 1053]
Pages: 6
DOI: 10.2174/138945008786949423
Price: $58

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