Different Synthetic Strategies of Oseltamivir Phosphate: A Potent Influenza Neuraminidase Inhibitor

Jianzhi      Gong; Wenfang      Xu

Abstract

Oseltamivir phosphate (Tamiflu®) is the only orally active anti-influenza drug that potently inhibit neuraminidase. The recent emergence of avian flu, especially the H5N1 type, makes the situation of Tamiflu supply and demand increasingly serious. Further optimization of the current commercial approach and exploration of new synthetic routes are urgent. Here, different synthetic strategies of oseltamivir phosphate are reviewed, including discovery and improved synthetic route from (-)-quinic acid or (-)-shikimic acid, new asymmetric synthesis via catalytic desymmetrization of a mesoaziridine (CDMA), Diels-Alder Reaction and from other available materials.

Keywords: Oseltamivir phosphate (Tamiflu), neuraminidase inhibitor, synthetic strategies

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Current Medicinal Chemistry

Title: Different Synthetic Strategies of Oseltamivir Phosphate: A Potent Influenza Neuraminidase Inhibitor

Volume: 15 Issue: 30

Author(s): Jianzhi Gong and Wenfang Xu

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Keywords: Oseltamivir phosphate (Tamiflu), neuraminidase inhibitor, synthetic strategies

Abstract: Oseltamivir phosphate (Tamiflu®) is the only orally active anti-influenza drug that potently inhibit neuraminidase. The recent emergence of avian flu, especially the H5N1 type, makes the situation of Tamiflu supply and demand increasingly serious. Further optimization of the current commercial approach and exploration of new synthetic routes are urgent. Here, different synthetic strategies of oseltamivir phosphate are reviewed, including discovery and improved synthetic route from (-)-quinic acid or (-)-shikimic acid, new asymmetric synthesis via catalytic desymmetrization of a mesoaziridine (CDMA), Diels-Alder Reaction and from other available materials.

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Cite this article as:

Gong Jianzhi and Xu Wenfang, Different Synthetic Strategies of Oseltamivir Phosphate: A Potent Influenza Neuraminidase Inhibitor, Current Medicinal Chemistry 2008; 15 (30) . https://dx.doi.org/10.2174/092986708786848497

DOI https://dx.doi.org/10.2174/092986708786848497	Print ISSN 0929-8673
Publisher Name Bentham Science Publisher	Online ISSN 1875-533X

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