Biodegradable Polymer Based Particulate Carrier(s) for the Delivery of Proteins and Peptides

Author(s): Neeraj Mishra, Amit K. Goyal, Kapil Khatri, Bhuvaneshwar Vaidya, Rishi Paliwal, Shivani Rai, Abhinav Mehta, Shailja Tiwari, Shiva Vyas, Suresh P. Vyas.

Journal Name: Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

Volume 7 , Issue 4 , 2008

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Abstract:

Construction of safe and effective delivery systems for proteins and peptides is demand of current clinical practices. Biodegradable polymers based particulates carriers fulfill much of the requirement in this applicable field. Number of marketed products related to biodegradable polymers encapsulating proteins is increasing. However, it has not achieved its proper place since problems related to the protein processing and stabilization limits the scientific community. In this present review we have summarized various aspects related to the formulation and processing of biodegradable polymerized microparticles/ nanoparticles for delivery of therapeutic proteins and peptides. A brief introduction of biodegradable polymers has been incorporated for readers benefit. In addition, biodegradable polymers based carriers designed for vaccine delivery has been incorporated in detail. Functionalized biodegradable carrier(s) for site specific delivery of proteineous matter has also been discussed.

Keywords: Biodegradable polymers, protein, peptide, vaccine, microparticles, nanoparticles, lectins, poloxamer, PEGylation

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Article Details

VOLUME: 7
ISSUE: 4
Year: 2008
Page: [240 - 251]
Pages: 12
DOI: 10.2174/187152308786847816
Price: $58

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