CDC25 Inhibitors as Anticancer Agents Are Moving Forward

Author(s): M.-C. Brezak, P. G. Kasprzyk, M.-O. Galcera, O. Lavergne, G. P. Prevost.

Journal Name:Anti-Cancer Agents in Medicinal Chemistry

Volume 8 , Issue 8 , 2008

Abstract:

The identification of a CDC25 inhibitor to arrest the cell cycle closely followed the discovery of CDC25 by Russell and Nurse in 1986. Recent advances at the preclinical and clinical stages reinforce the rationale to consider CDC25 as a relevant target for a cancer treatment. Here, in order to exemplify recent drug discovery efforts, we present our own experience with various chemical series of CDC25 inhibitors. We discuss how we have progressed and how we are considering the next steps to define the clinical entry points and hopefully complete this target validation to generate a new class of therapeutic agents.

Keywords: Cancer, phosphatase, CDC25, inhibitors, cell cycle, proliferation, agents, small molecules

Rights & PermissionsPrintExport

Article Details

VOLUME: 8
ISSUE: 8
Year: 2008
Page: [857 - 862]
Pages: 6
DOI: 10.2174/187152008786847701
Price: $58

Article Metrics

PDF: 7
HTML: 0
EPUB: 0
PRC: 0