Body Composition and -174G/C Interleukin-6 Promoter Gene Polymorphism: Association with Progression of Insulin Resistance in Normal Weight Obese Syndrome

Author(s): L. Di Renzo , A. Bertoli , M. Bigioni , V. Del Gobbo , M. G. Premrov , V. Calabrese , N. Di Daniele , A. De Lorenzo .

Journal Name: Current Pharmaceutical Design

Volume 14 , Issue 26 , 2008

Abstract:

Insulin resistance and obesity are intimately related to a chronic low grade systemic inflammation. Interleukin- 6 (IL-6) may influence the pathogenesis of obesity-related diseases. The aim of this study is to investigate the effect of bodys fat mass on the relationships between -174G/C IL-6 promoter gene polymorphism, IL-6 circulating level and insulin resistance. A population of 150 Caucasian women was studied, subdivided according to their body composition in non-obese (NW), Normal Weight Obese (NWO) and preobese-obese (OB). The NWO subjects were found in an intermediate position between the NW and OB subjects in terms of body weight, fat mass percentage (FM%), abdominal FAT%, hs-CRP and plasma triglyceride level. Fasting plasma IL-6 concentration was positively correlated with the homeostasis model assessment for insulin resistance (HOMA-IR) in all subjects analyzed (P=0.0014). In NWO and OB women a significantly increased IL-6 mean value was observed compared with NW subjects. In G/G population, the IL-6 plasma level of NWO and OB was significantly higher with respect to NW. No significant differences of IL-6 concentrations were observed in the three groups carrying G/C genotype. NWO and OB women homozygous for the allele C have significantly lower value of IL-6 with respect to NW subjects. IL-6 concentration was positively correlated with FM% in G/G (R2=0.397, P < 0.001) and was negatively correlated in C/C (R2=0.459, P=0.002). No significant correlation was observed in G/C genotype (R2=0.041, P=0.173). In conclusion our study confirms that, at least in Italian Caucasian females, the FM% is a major determinant of an increase in IL-6 production and insulin resistance. -174 G/C IL-6 promoter polymorphism represents a marker which could help to identify, time in advance, “vulnerable” individuals at risk of age and obesity related diseases.

Keywords: IL-6 -174 G/C promoter polymorphism, obesity, insulin resistance, body composition, obesity related diseases

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Article Details

VOLUME: 14
ISSUE: 26
Year: 2008
Page: [2699 - 2706]
Pages: 8
DOI: 10.2174/138161208786264061
Price: $58

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