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Current Pharmaceutical Design
ISSN (Print): 1381-6128
ISSN (Online): 1873-4286
VOLUME: 14
ISSUE: 26
DOI: 10.2174/138161208786264197      Price:  $58









Relationship Among Fatty Liver, Adipose Tissue Distribution and Metabolic Profile in Moderately Obese Children: An Ultrasonographic Study

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Author(s): M. Chiloiro, G. Riezzo, S. Chiarappa, M. Correale, V. Guerra, L. Amati, M. R. Noviello and E. Jirillo
Pages 2693-2698 (6)
Abstract:
We examined the relationship between moderate obesity and glucose metabolism, insulin sensitivity and suspected fatty liver in children. We measured body mass index (BMI), z-score BMI, caliper skinfold thickness, waist and hip circumference in 94 participants (mean age 9.7 ±2.2 years). Fasting blood glucose, insulin, HOMA score, lipid profile and transaminases (ALT, AST) were measured. Fatty liver and skinfold thickness were evaluated by means of ultrasound. The z-score BMI was 2.01 ±0.39 (mean ± SD), and the duration of obesity was 4.3±3.03 years. A positive correlation was found between caliper and US skinfold thickness for tricipital (r= 0.33; p= 0.003) and sovrailiac skinfold (r= 0.34; p=0.003). Fatty liver was diagnosed in 64% of children and it was positively related to anthropometric measurements. The three sub-groups – group 0 (normal US liver and normal transaminases); group 1 (US fatty liver and normal transaminases); group 2 (US fatty liver and elevated transaminases) – showed a difference concerning z-score BMI, insulin and HOMA parameters (Tukey test: z score BMI group 1 vs group 0 and 2 vs group 0; serum insulin: group 2 vs group 1 and group 2 vs group 0; HOMA IR: group 2 vs group 1 and group 2 vs group 0). Moderately obese children with steatosis exhibited a clear increase of insulin and insulin resistance which represents indices of a future metabolic syndrome. In addition, it is important to perform a liver ultrasound since transaminases seems to be not adequate for the diagnosis of fatty liver.
Keywords:
Fatty liver, obesity, children, anthropometric measurement, ultrasound
Affiliation:
Radiology Unit, IRCCS “S de Bellis”, Via Turi, 70013 Castellana Grotte (BA), Italy.