Polyethylenimine In Medicinal Chemistry

Author(s): Paola Vicennati, Antonella Giuliano, Giancarlo Ortaggi, Andrea Masotti.

Journal Name: Current Medicinal Chemistry

Volume 15 , Issue 27 , 2008

Abstract:

Polyethylenimine (PEI), an organic branched or linear polyamine polymer, has been successfully used in the past for DNA complexation and transfection in vitro and in vivo into several cell lines and tissues. PEI was also applied in different fields from gene therapy and several studies have emphasized the importance of this polymer in medicinal chemistry. In this brief critical review the uses and applications of this versatile polymeric molecule will be discussed.

Keywords: Polyethylenimine, polymer, DNA, transfection, gene therapy, drug delivery, medicinal chemistry, biomedical applications

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Article Details

VOLUME: 15
ISSUE: 27
Year: 2008
Page: [2826 - 2839]
Pages: 14
DOI: 10.2174/092986708786242778
Price: $58

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