Phase Transition System: Novel Oral In-Situ Gel

Author(s): Ramesh C. Nagarwal, J. K. Pandit.

Journal Name: Current Drug Delivery

Volume 5 , Issue 4 , 2008

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Abstract:

Inspite of the various impediments in the bioavailability of orally delivered drugs, oral dosage forms, both solid and liquid, occupy a center stage in the therapeutic regimen of diseases. However, liquid dosage forms are more prone to low bioavailability because of their quick transit from the stomach/ duodenum. This could be a serious problem for drugs, which are absorbed from these sites of the GIT. The gastric retention of an oral liquid formulation could be successfully augmented substantially through a strategy of liquid in-situ gelling system. Natural polymers like alginate, gellan and chitosan can undergo sol to gel transformation in the presence of either divalent cations or due to a change in pH. The gel so formed, being lighter than gastric fluids, floats over the stomach contents and is retained there in for periods upto 24 hours. The in-situ gel formation enhances the local or systemic bioavailability of the administered drug. This concept is a redesign of liquid oral dosage form, which fulfills the requirement for a sustained release liquid preparation. This review discusses the various aspects associated with the in-situ gelling systems and their therapeutic applications.

Keywords: In-situ gel, phase transition, gastro-retentive, sodium alginate, gellan, pectin

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Article Details

VOLUME: 5
ISSUE: 4
Year: 2008
Page: [282 - 289]
Pages: 8
DOI: 10.2174/156720108785914952
Price: $58

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