Novel Diaryl or Heterocyclic Sulfonamides as Antimitotic Agents
Laixing Hu, Zhuo-rong Li, Jian-dong Jiang and David W. Boykin
Affiliation: Department of Chemistry and Center for Biotechnology and Drug Design, Georgia State University, Atlanta, GA 30303, USA.
Keywords: Antimitotic Agents, Heterocyclic Sulfonamides, anticarbonic anhydrase, hypoglycemic, potent anticancer agents, tumor cell, structure-activity relationships (SAR)
The sulfonamides constitute an important class of drugs, which display a variety of activities including antibacterial, anticarbonic anhydrase, diuretic, hypoglycemic and antithyroid effectiveness. A number of sulfonamides have been reported to be potent anticancer agents, which interact with a wide range of different cellular targets. Among these interesting sulfonamides, the diaryl or heterocyclic sulfonamides have recently emerged as an important class of antimitotic agents against different types of cancer, including multidrug resistant tumors. This review summarizes the recent advances of the diaryl or heterocyclic sulfonamides as novel antimitotic agents.
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