Abstract
Calcium is a ubiquitous second messenger and is involved in virtually all cellular functions. Cellular events being regulated by calcium include gene transcription, metabolism, proliferation and apoptosis. Cancer growth is based on increased proliferation, decreased differentiation and decreased apoptosis. Therefore, the intracellular Ca2+-homeostasis has become one of the focuses in current cancer research. Elevation of the cytoplasmic Ca2+-concentration can result from Ca2+-influx from the extracellular space or from Ca2+-release from intracellular stores. The main intracellular Ca2+-store is the endoplasmic reticulum (ER). The Ca2+-content of the ER is maintained by trans-membrane proteins involving the sarco/endoplasmic reticulum Ca2+-ATPase and the inositol-1,4,5-phosphat receptor. In this review, we summarize the current knowledge of the ER and its trans-membrane proteins as regulating structures of the intracellular Ca2+- homeostasis, what changes occur in malignant cells and how this promotes cancer. We further review possible pharmacological intervention and show future perspectives of the intracellular Ca2+-homeostasis as an anti-cancer target.
Keywords: Cancer, endoplasmic reticulum, calcium, SERCA, IP3R
Anti-Cancer Agents in Medicinal Chemistry
Title: Regulation of the Endoplasmic Reticulum Ca2+-Store in Cancer
Volume: 8 Issue: 7
Author(s): A. Bergner and R. M. Huber
Affiliation:
Keywords: Cancer, endoplasmic reticulum, calcium, SERCA, IP3R
Abstract: Calcium is a ubiquitous second messenger and is involved in virtually all cellular functions. Cellular events being regulated by calcium include gene transcription, metabolism, proliferation and apoptosis. Cancer growth is based on increased proliferation, decreased differentiation and decreased apoptosis. Therefore, the intracellular Ca2+-homeostasis has become one of the focuses in current cancer research. Elevation of the cytoplasmic Ca2+-concentration can result from Ca2+-influx from the extracellular space or from Ca2+-release from intracellular stores. The main intracellular Ca2+-store is the endoplasmic reticulum (ER). The Ca2+-content of the ER is maintained by trans-membrane proteins involving the sarco/endoplasmic reticulum Ca2+-ATPase and the inositol-1,4,5-phosphat receptor. In this review, we summarize the current knowledge of the ER and its trans-membrane proteins as regulating structures of the intracellular Ca2+- homeostasis, what changes occur in malignant cells and how this promotes cancer. We further review possible pharmacological intervention and show future perspectives of the intracellular Ca2+-homeostasis as an anti-cancer target.
Export Options
About this article
Cite this article as:
Bergner A. and Huber M. R., Regulation of the Endoplasmic Reticulum Ca2+-Store in Cancer, Anti-Cancer Agents in Medicinal Chemistry 2008; 8 (7) . https://dx.doi.org/10.2174/187152008785914734
DOI https://dx.doi.org/10.2174/187152008785914734 |
Print ISSN 1871-5206 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5992 |
Call for Papers in Thematic Issues
Induction of cell death in cancer cells by modulating telomerase activity using small molecule drugs
Telomeres are distinctive but short stretches present at the corners of chromosomes and aid in stabilizing chromosomal makeup. Resynthesis of telomeres supported by the activity of reverse transcriptase ribonucleoprotein complex telomerase. There is no any telomerase activity in human somatic cells, but the stem cells and germ cells undergone telomerase ...read more
Role of natural compounds as anti anti-cancer agents
Cancer is considered the leading cause of worldwide mortality, accounting for nearly 10 million deaths in 2022. Cancer outcome can be improved through an appropriate screening and early detection and through an efficient clinical treatment. Chemotherapy remains an important approach in treatment o f several types of cancers, even though ...read more
Signaling and enzymatic modulators in cancer treatment
Cancer accounts for nearly 10 million deaths in 2022 and is considered the leading cause of worldwide mortality. Cancer outcome can be improved through an appropriate screening and early detection and through an efficient clinical treatment. Chemotherapy, radiotherapy and surgery are the most important approach for the treatment of several ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Adenosine A<sub>3</sub> Receptor: A promising therapeutic target in cardiovascular disease
Current Cardiology Reviews Vasotrophic Regulation of Age-Dependent Hypoxic Cerebrovascular Remodeling
Current Vascular Pharmacology Molecular Chaperone Activity and Biological Regulatory Actions of the TPR-Domain Immunophilins FKBP51 and FKBP52
Current Protein & Peptide Science Bladder Cancer and Stem Cells
Current Signal Transduction Therapy A Review of Natural and Synthetic Antioxidants Important for Health and Longevity
Current Medicinal Chemistry Plants vs. Cancer: A Review on Natural Phytochemicals in Preventing and Treating Cancers and Their Druggability
Anti-Cancer Agents in Medicinal Chemistry Transmission Electron Microscopy as Key Technique for the Characterization of Telocytes
Current Stem Cell Research & Therapy Pharmacological Inhibitors of NAD Biosynthesis as Potential An ticancer Agents
Recent Patents on Anti-Cancer Drug Discovery Extending the Clinical Horizons of Mucosal Bacterial Vaccines: Current Evidence and Future Prospects
Current Drug Targets Herbal Medicines for Diabetes Management and its Secondary Complications
Current Diabetes Reviews Transcriptionally Targeted Adenovirus Vectors
Current Gene Therapy Role of mTOR in Hematological Malignancies
Current Cancer Therapy Reviews Anticancer α-Helical Peptides and Structure / Function Relationships Underpinning Their Interactions with Tumour Cell Membranes
Current Protein & Peptide Science CD147 Interacts with NDUFS6 in Regulating Mitochondrial Complex I Activity and the Mitochondrial Apoptotic Pathway in Human Malignant Melanoma Cells
Current Molecular Medicine Preparation and Primary Bioevaluation of 99mTc-labeled-1-thio-β-D-Glucose as Melanoma Targeting Agent
Current Radiopharmaceuticals The Significance of COX-2 and COX-2 Inhibitors in Liver Fibrosis and Liver Cancer
Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents The Role of Diabetes in Molecular Pathogenesis of Cancer
Current Signal Transduction Therapy Seq and You Will Find
Current Gene Therapy Hollow Inorganic Nanoparticles as Efficient Carriers for siRNA Delivery: A Comprehensive Review
Current Pharmaceutical Design Targeted Cancer Therapy: The Next Generation of Cancer Treatment
Current Drug Discovery Technologies