Protein Kinase Inhibitors in the Treatment of Pulmonary Fibrosis

Author(s): Sylvie Garneau-Tsodikova , Victor J. Thannickal .

Journal Name: Current Medicinal Chemistry

Volume 15 , Issue 25 , 2008

Abstract:

Fibrosis of the lung and other organ systems is an increasing cause of morbidity and mortality worldwide. Effective anti-fibrotic agents for such disorders are currently lacking. Injury to epithelium-lined tissues in mammals is typically associated with a mesenchymal response, including the activation of myofibroblasts. Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal disease that results from effacement of the normal alveolar architecture of the lung. Loss of lung capacity for gas-exchange and increased work of breathing eventually leads to respiratory failure and death. In cutaneous wound models, apoptosis of myofibroblasts are essential to scar-less wound healing. Recent studies indicate that acquisition of an apoptosis-resistant myofibroblast phenotype in the injured lung is associated with non-resolving and persistent fibrosis. The acquired resistance to apoptosis in myofibroblasts is mediated, at least in part, by the sustained activation of two critical pro-survival protein kinases, focal adhesion kinase (FAK) and protein kinase B (PKB/AKT). Therapeutic interventions that modulate the activity of these protein kinases with resultant alterations in the phenotype of myofibroblasts may prove to be effective anti-fibrotic therapeutic strategies. We discuss the potential roles for protein kinase inhibitors as novel drugs for fibrotic disorders. Progress in pre-clinical and clinical development of small molecule inhibitors targeting pro-survival protein kinases is reviewed.

Keywords: Fibrosis, protein kinase inhibitors, therapeutics, apoptosis, focal adhesion kinase, protein kinase B, fibroblasts, epithelial cells

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Article Details

VOLUME: 15
ISSUE: 25
Year: 2008
Page: [2632 - 2640]
Pages: 9
DOI: 10.2174/092986708785908969
Price: $58

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