Peroxisome Proliferator-Activated Receptor-γ (PPAR-γ) Ligands: Novel Pharmacological Agents in the Treatment of Ischemia Reperfusion Injury

Author(s): Costas Giaginis, Gerasimos Tsourouflis, Stamatios Theocharis.

Journal Name: Current Molecular Medicine

Volume 8 , Issue 6 , 2008

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Abstract:

Peroxisome proliferator-activated receptor-γ (PPAR-γ) ligands constitute important insulin sensitizers that have already been used for the treatment of human metabolic disorders, exerting also pleiotropic effects on inflammatory related diseases and cancer. Ischemia-reperfusion injury that is mainly associated with organ transplantation constitutes a serious complication with a great relevance in clinical practice. Accumulating experimental data have recently revealed that natural and synthetic PPAR-γ ligands exert beneficial effects against ischemia-reperfusion injury. The present review summarizes the available information on the role of PPAR-γ ligands in ischemia-reperfusion injury amongst the different organ systems. Taking into consideration the data so far, PPAR-γ ligands seem to represent potential therapeutic agents in the aim to reduce or even prevent injury associated with ischemia-reperfusion.

Keywords: Ischemia Reperfusion Injury, Peroxisome proliferator-activated receptor-γ (PPAR-γ), insulin sensitizers, human metabolic disorders, inflammatory, growth hormone protein-1 (GHP-1)

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Article Details

VOLUME: 8
ISSUE: 6
Year: 2008
Page: [562 - 579]
Pages: 18
DOI: 10.2174/156652408785748022
Price: $58

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