Current Computer-Aided Drug Design

Subhash C. Basak
Departments of Chemistry, Biochemistry & Molecular Biology University of Minnesota Duluth
Duluth, MN 55811
USA

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Combining Ligand- and Structure-Based Methods in Drug Design Projects

Author(s): Olivier Sperandio, Maria A. Miteva, Bruno O. Villoutreix.

Abstract:

In todays drug discovery projects, the use of virtual screening tools, either ligand-based or structure-based techniques, is gaining momentum. Taken separately, these techniques obviously present some genuine advantages on some specific tasks, for example and for a given target, it is possible to explore the local variation of the chemical space in terms of structure activity relationship (SAR), or to sample the pharmaco-topological profile of potential hit molecules in a target structure driven manner (docking). Thus, while inherent limits are associated with each of these screening techniques that are not about to be easily solved, their combination in a hybrid protocol can help to balance these limitations and capitalize on their mutual strengths. Here we review some recent studies integrating ligand- and structure-based screening protocols, and show how this concept directly benefits the quality of the hit molecules.

Keywords: Drug design, structure-based drug design, ligand-based drug design, pharmacophore, QSAR, virtual screening, combination

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Article Details

VOLUME: 4
ISSUE: 3
Year: 2008
Page: [250 - 258]
Pages: 9
DOI: 10.2174/157340908785747447
Price: $58