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Current Clinical Pharmacology

Editor-in-Chief

ISSN (Print): 1574-8847
ISSN (Online): 2212-3938

Fixed Dose Combination of Cefepime Plus Amikacin Prevent Oxidative Stress in Liver of Mus musculus Mice

Author(s): Manu Chaudhary, Arvind Soni and Vivek Kumar Dwivedi

Volume 3, Issue 3, 2008

Page: [211 - 214] Pages: 4

DOI: 10.2174/157488408785747683

Price: $65

Abstract

Oxidative stress and free radical are causative factors for aminoglycoside induced tissue injury. The objective of present study was to evaluate effect of fixed dose combination of cefepime + amikacin on antioxidant enzymes such as superoxide dismutase (SOD), catalase along with malonaldialdehyde (MDA) levels in liver of Mus musculus mice. Our findings showed that the activities of the antioxidant enzymes such as superoxide dismutase (p < 0.001, 62.2%), catalase (p < 0.05, 47.5%) were significantly lowered along with increase in the MDA levels (66.0%) after the single treatment of amikacin as compared to control group. A significant improvement in the activities of superoxide dismutase and catalase along with decrease in MDA levels were observed in fixed dose combination of cefepime plus amikacin treated groups as compared to amikacin alone treated group. These findings suggest that the fixed dose combination therapy of cefepime + amikacin (Potentox) show significant free radical scavenging property which may contribute to decrease in aminoglycoside induced liver injury.

Keywords: Amikacin, antioxidant enzymes, cefepime plus amikacin, fixed dose combination, malonaldialdehyde

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