Adhesion Molecules in Lung Cancer: Implications in the Pathogenesis and Management

Author(s): Kostas N. Syrigos, Nikos Katirtzoglou, Elias Kotteas, Kevin Harrington.

Journal Name: Current Pharmaceutical Design

Volume 14 , Issue 22 , 2008

Become EABM
Become Reviewer

Abstract:

Growth and metastasis of lung cancer requires a sequence of events, which alter the ability of neoplastic cells to adhere to themselves, to normal surrounding cells, or to the extracellular matrix. Interactions between cells are primarily mediated by four types of structures in the plasma membrane: gap junctions, tight junctions, desmosomes, and adherence junctions. We have reviewed the existing data on the implication of adhesion molecules in the pathogenesis of lung cancer, as well as the application of certain adhesion molecules as potential surrogate markers in lung cancer patients.

Keywords: cadherins, catenins, integrins, selectins, ICAMS, VEGF, CEA

Rights & PermissionsPrintExport Cite as

Article Details

VOLUME: 14
ISSUE: 22
Year: 2008
Page: [2173 - 2183]
Pages: 11
DOI: 10.2174/138161208785740162
Price: $58

Article Metrics

PDF: 6