Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

(Formerly Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents)

Bahar Tunctan
Department of Pharmacology
Faculty of Pharmacy
Mersin University
Mersin, 33169
Turkey

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Atherosclerosis and Inflammation: Insight from Carotid and Intracoronary Ultrasound Studies

Author(s): Syed Tahir, Anthony Nappi, Navin K. Kapur.

Abstract:

Dating back to the early 1900s, clinical observations have pointed towards an intimate relationship between dyslipidemia, inflammation, and endothelial dysfunction in the pathogenesis of atherosclerosis. Despite a focus on aggressive lowering of low-density lipoprotein cholesterol (LDL-C) in patients at risk for developing cardiovascular disease, only moderate reductions in cardiovascular events have been achieved, suggesting other targets of therapy should be investigated. Over the past two decades pre-clinical and clinical data have demonstrated a direct correlation between inflammation and atheroma development. This review provides a detailed understanding of inflammation in atherogenesis with a particular emphasis on clinical studies correlating markers of inflammation with plaque progression using carotid intima-media thickness measurements and intravascular ultrasound.

Keywords: Atherosclerosis, inflammation, atherogenesis, soluble markers, intravascular ultrasound, carotid intima-media thickness.

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Article Details

VOLUME: 7
ISSUE: 3
Year: 2008
Page: [231 - 238]
Pages: 8
DOI: 10.2174/187152308785699227
Price: $58