Runx1/AML1 is a Guardian of Hematopoietic Stem Cells

Author(s): Lena Motoda, Motomi Osato, Yoshiaki Ito.

Journal Name:Current Cancer Therapy Reviews

Volume 4 , Issue 3 , 2008

Abstract:

An oncogenic stimulus in a cell primarily results in hyperproliferation. However, uncontrolled cell proliferation is sensed by the cell and triggers a fail-safe mechanism resulting in senescence, apoptosis, or differentiation. This phenomenon is considered to be a cellular fail-safe mechanism to eliminate undesirable cells from a population of healthy cells. The RUNX1/AML1 gene, one of the most frequently targeted genes in human leukemia, is induced by the Ras oncogene in hematopoietic stem/progenitor cells and required to maintain the fail-safe mechanism. The stem cell pool is thereby protected from oncogenic insults and cancer-initiating cells, which would become cancer stem cells after accumulation of sequential genetic changes, are eliminated. This fail-safe mechanism and the consequence of its disruption in oncogenesis seems to be a fundamentally important concept, but have not been fully recognized to date. Gaining a better understanding of this mechanism might lead to new strategies to treat cancer stem cell-associated resistance to chemotherapy which is the subject of intense discussion in recent years.

Keywords: Runx, leukemia stem cell, cancer stem cell, senescence, apoptosis

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Article Details

VOLUME: 4
ISSUE: 3
Year: 2008
Page: [188 - 195]
Pages: 8
DOI: 10.2174/157339408785294302