Hyaluronan Oligosaccharides as a Potential Anticancer Therapeutic

Author(s): Bryan P. Toole , Shibnath Ghatak , Suniti Misra .

Journal Name: Current Pharmaceutical Biotechnology

Volume 9 , Issue 4 , 2008

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Abstract:

Hyaluronan (HA) polysaccharide has differential effects on cells depending on polymer size. One of the more exciting findings is that small chains or oligosaccharides of HA (6-18 sugar units), but not large polymers, will kill many types of cancer cells by triggering apoptosis while leaving normal cells unaffected. Even chemoresistant cells become drug-sensitive when co-treated with HA oligosaccharides. Overall, these observations form the basis for new anticancer therapeutics.

Keywords: Cancer, metastasis, CD44, signaling, apoptosis

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Article Details

VOLUME: 9
ISSUE: 4
Year: 2008
Page: [249 - 252]
Pages: 4
DOI: 10.2174/138920108785161569
Price: $58

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