Monodisperse Hyaluronan Polymers: Synthesis and Potential Applications

Author(s): Paul L. DeAngelis .

Journal Name: Current Pharmaceutical Biotechnology

Volume 9 , Issue 4 , 2008

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In many cases, the cellular response to hyaluronan (HA) depends on the molecular weight (MW) of the polymer chain. Most HA preparations from Nature or its derivatives possess wide size distributions called polydisperse. New chemoenzymatic synthesis technology allows the production of very narrow size distribution polymers called monodisperse. The use of stoichiometrically controlled and synchronized polymerization reactions allows an assortment of new HA reagents in the range of 10 kDa to 2,500 kDa for answering HA biology questions or potentially treating disease.

Keywords: Hyaluronic acid, synthase, Pasteurella, size control, molecular mass

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Article Details

Year: 2008
Page: [246 - 248]
Pages: 3
DOI: 10.2174/138920108785161550
Price: $58

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