Chemically-Modified HA for Therapy and Regenerative Medicine
Glenn D. Prestwich and Jing-wen Kuo
Affiliation: Department of Medicinal Chemistry and Center for Therapeutic Biomaterials,The University of Utah, 419 Wakara Way, Suite 205, Salt Lake City, Utah 84108, USA.
Hyaluronan (HA) is a very useful polymer, but its properties sometimes need to be altered or enhanced by chemical modification for biomedical applications. A wide variety of HA derivatives are currently used for eye surgery, joint viscoelastic supplementation, and anti-adhesion films. The future promises to deliver new classes of HA-based reagents as well as new polymers that can be used in situ with living cells or within the body.
Keywords: Cross-linking, gels, scaffolds, biomaterials
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