Current Pharmaceutical Biotechnology

Zeno Foldes-Papp
Visiting Professor of Medical Biochemistry
HELIOS Clinical Center of Emergency Medicine
Department for Internal Medicine
Alte-Koelner-Strasse 9
D-51688 Koeln-Wipperfuerth
Germany

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Chemically-Modified HA for Therapy and Regenerative Medicine

Author(s): Glenn D. Prestwich and Jing-wen Kuo

Affiliation: Department of Medicinal Chemistry and Center for Therapeutic Biomaterials,The University of Utah, 419 Wakara Way, Suite 205, Salt Lake City, Utah 84108, USA.

Abstract:

Hyaluronan (HA) is a very useful polymer, but its properties sometimes need to be altered or enhanced by chemical modification for biomedical applications. A wide variety of HA derivatives are currently used for eye surgery, joint viscoelastic supplementation, and anti-adhesion films. The future promises to deliver new classes of HA-based reagents as well as new polymers that can be used in situ with living cells or within the body.

Keywords: Cross-linking, gels, scaffolds, biomaterials

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Article Details

VOLUME: 9
ISSUE: 4
Page: [242 - 245]
Pages: 4
DOI: 10.2174/138920108785161523
Price: $58