Abstract
Prostaglandin D2 (PGD2) is a major prostanoid produced mainly by mast cells in allergic diseases, including bronchial asthma. However, its role in the pathogenesis of asthma remains unclear. PGD2-induced vasodilatation and increased permeability are well-known classical effects that may facilitate transendothelial migration of inflammatory cells, such as eosinophils, mast cells, lymphocytes, and monocytes in allergic inflammation. These effects are initiated via a PGD2 receptor, D prostanoid receptor (DP), and are referred to as DP-mediated vasodilation-extravasation. Recently, novel functions of DP have been identified. Furthermore, a novel and different receptor of PGD2, CRTH2, has been discovered. To date, DP and CRTH2 have been shown to be major PGD2-related receptors that have pivotal roles in mediating allergic diseases by effects such as directly regulating the migration of inflammatory cells and controlling the production of cytokines and lipid mediators. Available evidence suggests that CRTH2 and DP may collaborate in allergic inflammation. This review focuses on the novel roles of DP and CRTH2 in the initiation and maintenance of allergy.
Keywords: Basophils, bronchial asthma, eosinophils, mast cells, prostanoids, Th2 cells
Current Molecular Medicine
Title: Prostaglandin D2 Receptors DP and CRTH2 in the Pathogenesis of Asthma
Volume: 8 Issue: 5
Author(s): Masafumi Arima and Takeshi Fukuda
Affiliation:
Keywords: Basophils, bronchial asthma, eosinophils, mast cells, prostanoids, Th2 cells
Abstract: Prostaglandin D2 (PGD2) is a major prostanoid produced mainly by mast cells in allergic diseases, including bronchial asthma. However, its role in the pathogenesis of asthma remains unclear. PGD2-induced vasodilatation and increased permeability are well-known classical effects that may facilitate transendothelial migration of inflammatory cells, such as eosinophils, mast cells, lymphocytes, and monocytes in allergic inflammation. These effects are initiated via a PGD2 receptor, D prostanoid receptor (DP), and are referred to as DP-mediated vasodilation-extravasation. Recently, novel functions of DP have been identified. Furthermore, a novel and different receptor of PGD2, CRTH2, has been discovered. To date, DP and CRTH2 have been shown to be major PGD2-related receptors that have pivotal roles in mediating allergic diseases by effects such as directly regulating the migration of inflammatory cells and controlling the production of cytokines and lipid mediators. Available evidence suggests that CRTH2 and DP may collaborate in allergic inflammation. This review focuses on the novel roles of DP and CRTH2 in the initiation and maintenance of allergy.
Export Options
About this article
Cite this article as:
Arima Masafumi and Fukuda Takeshi, Prostaglandin D2 Receptors DP and CRTH2 in the Pathogenesis of Asthma, Current Molecular Medicine 2008; 8 (5) . https://dx.doi.org/10.2174/156652408785160970
DOI https://dx.doi.org/10.2174/156652408785160970 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Damage-Associated Molecular Patterns – Emerging Targets for Biologic Therapy of Childhood Arthritides
Inflammation & Allergy - Drug Targets (Discontinued) Selective Chemokine Receptor-Targeted Depletion of Pathological Cells as A Therapeutic Strategy for Inflammatory, Allergic and Autoimmune Diseases
Recent Patents on Inflammation & Allergy Drug Discovery An Overview on Pyranocoumarins: Synthesis and Biological Activities
Current Organic Chemistry Defining the Role of Food Allergy in a Population of Adult Patients with Eosinophilic Esophagitis
Inflammation & Allergy - Drug Targets (Discontinued) Association of Serum Malondialdehyde and C-reactive Protein Levels with Exacerbations of Chronic Obstructive Pulmonary Disease
Current Respiratory Medicine Reviews Novel Strategies for the Treatment of Asthma
Recent Patents on Inflammation & Allergy Drug Discovery Involvement of Tachykinins in Intestinal Inflammation
Current Pharmaceutical Design Activated Immune System and Inflammation in Healthy Ageing: Relevance for Tryptophan and Neopterin Metabolism
Current Pharmaceutical Design Anti-inflammatory Phytochemicals for Chemoprevention of Colon Cancer
Current Cancer Drug Targets Antimicrobial and Anti-MRSA Effects of Three Extracts of Some Hypericum Species Against Standard Microorganisms and Methicillin Resistant Staphylococcus aureus (MRSA) Strains
Current Bioactive Compounds C1-Inhibitor: Structure, Functional Diversity and Therapeutic Development
Current Medicinal Chemistry Pipeline Pharmacogenetics: A Novel Approach to Integrating Pharmacogenetics into Drug Development
Current Pharmaceutical Design The Mast Cell Pathway to Inflammation and Homeostasis: Pharmacolo- gical Insights
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Structure-Based Discovery of PDEs Inhibitors
Current Topics in Medicinal Chemistry Curcumin: Structure-Activity Relationship Towards its Role as a Versatile Multi-Targeted Therapeutics
Mini-Reviews in Organic Chemistry A Review of Select Recent Patents on Novel Nanocarriers
Recent Patents on Drug Delivery & Formulation Development of Colon Specific Microspheres of Flurbiprofen for Inflammatory Bowel Disease
Current Drug Delivery The Metabolic Fate of Apple Polyphenols in Humans
Current Nutrition & Food Science Dichotomous Life of DNA Binding High Mobility Group Box1 Protein in Human Health and Disease
Current Protein & Peptide Science Editorial: Premenstrual Syndrome and Dyspnea: Where is the Data?
Current Respiratory Medicine Reviews