Current Medicinal Chemistry

Atta-ur-Rahman, FRS
Honorary Life Fellow
Kings College
University of Cambridge
Cambridge
UK

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Platelet-Monocyte Interactions - A Dangerous Liaison Linking Thrombosis, Inflammation and Atherosclerosis

Author(s): Peter Seizer, Meinrad Gawaz, Andreas E. May.

Abstract:

Atherosclerosis is an inflammatory disease. Monocyte-platelet interactions may play a key role in this process by various pathways. They “inflame” each other as well as adjacent cell types at the vascular wall by direct physical interactions, autocrine and paracrine activation processes. These processes promote monocyte recruitment (in)to the vascular wall – a key mechanism in atherogenesis. This article highlights the molecular basis and the inflammatory pathways initiated by platelet – monocyte interactions.

Keywords: Atherosclerosis, Thrombosis, inflammatory disease, Monocyte-platelet interactions, Receptor, Cytokine

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Article Details

VOLUME: 15
ISSUE: 20
Year: 2008
Page: [1976 - 1980]
Pages: 5
DOI: 10.2174/092986708785132852
Price: $58