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Current Medicinal Chemistry
ISSN (Print): 0929-8673
ISSN (Online): 1875-533X
VOLUME: 15
ISSUE: 20
DOI: 10.2174/092986708785132852      Price:  $58









Platelet-Monocyte Interactions - A Dangerous Liaison Linking Thrombosis, Inflammation and Atherosclerosis

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Author(s): Peter Seizer, Meinrad Gawaz and Andreas E. May
Pages 1976-1980 (5)
Abstract:
Atherosclerosis is an inflammatory disease. Monocyte-platelet interactions may play a key role in this process by various pathways. They “inflame” each other as well as adjacent cell types at the vascular wall by direct physical interactions, autocrine and paracrine activation processes. These processes promote monocyte recruitment (in)to the vascular wall – a key mechanism in atherogenesis. This article highlights the molecular basis and the inflammatory pathways initiated by platelet – monocyte interactions.
Keywords:
Atherosclerosis, Thrombosis, inflammatory disease, Monocyte-platelet interactions, Receptor, Cytokine
Affiliation:
Medizinische Klinik III, Universitatsklinikum Tubingen, Otfried-Muller Str.10, 72076 Tubingen, Germany.