Anti-Cancer Agents in Medicinal Chemistry

(Formerly Current Medicinal Chemistry - Anti-Cancer Agents)

Michelle Prudhomme  
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France

Back

Bacteriochlorophyll a and Its Derivatives: Chemistry and Perspectives for Cancer Therapy

Author(s): Mikhail A. Grin, Andrey F. Mironov, Alexander A. Shtil.

Abstract:

The review summarizes the chemistry of the third generation of photosensitizers, namely, the derivatives of natural bacteriochlorophyll a for photodynamic treatment of cancer. The compounds of this class strongly absorb light at λ=770-850 nm. This unique property opens new therapeutic opportunities due to deeper tissue penetration of light, thereby increasing the photodamage for tumor eradication. Analyzed are the modifications of bacteriochlorophyll a that improve physico-chemical characteristics of compounds and enhance accumulation in tumors. Focusing on the delivery of photosensitizers to the tumor site and to specific intracellular compartments, we describe the conjugates of bacteriochlorophyll a derivatives with carbohydrate and protein carriers. Boronated bacteriochlorins can be used in both photodynamic and boron neutron capture therapy.

Keywords: Cancer Therapy, Bacteriochlorophyll a, photosensitizers, photodynamic treatment, tumor eradication, boron neutron capture therapy

Order Reprints Order Eprints Rights & PermissionsPrintExport

Article Details

VOLUME: 8
ISSUE: 6
Year: 2008
Page: [683 - 697]
Pages: 15
DOI: 10.2174/187152008785133128
Price: $58