Chronic Graft-Versus-Host Disease

Author(s): Javier Bolanos-Meade , Georgia B. Vogelsang .

Journal Name: Current Pharmaceutical Design

Volume 14 , Issue 20 , 2008


Chronic graft-versus-host disease is the most common late, non-relapse complication of transplantation yet it is also one of the least studied. It is the primary cause of morbidity and mortality of long-term survivors of allogeneic bone marrow transplants. Like acute graft-versus-host disease, it does have a strong antitumor effect. The recent National Institutes of Health sponsored Chronic Graft-versus- Host Disease Consensus Conference has proposed new criteria for diagnosis and staging, pathology, biomarkers, response and supportive care. New understanding of the pathophysiology of chronic graft-versus-host disease (i.e. the role of B cells) is already having an impact on therapy. Novel agents such as pentostatin, mycophenolate mofetil, rituximab, extracorporeal photochemotherapy, etc. are improving the outcome of steroid refractory chronic graft-versus-host disease.

Keywords: Host Disease, Chronic graft, antitumor effect, pathology, Novel agents, pentostatin, mycophenolate mofetil, extracorporeal photochemotherapy, rituximab

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Article Details

Year: 2008
Page: [1974 - 1986]
Pages: 13
DOI: 10.2174/138161208785061373
Price: $58

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