The Potential for Targeting Oncogenic WNT/β -Catenin Signaling in Therapy

Author(s): Kenneth B.R. Ewan, Trevor C. Dale.

Journal Name: Current Drug Targets

Volume 9 , Issue 7 , 2008

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Abstract:

There has been a surge of interest in the therapeutic targeting of the Wnt pathway following the demonstration that it is activated in a wide variety of tumors and that blocking aberrant signaling promoted tumor cell apoptosis or differentiation. This review describes recent therapeutic approaches and discusses potential opportunities for intervention at multiple levels within the Wnt pathway.

Keywords: Wnt, β-catenin, signaling, dysregulation, cancer, therapy

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Article Details

VOLUME: 9
ISSUE: 7
Year: 2008
Page: [532 - 547]
Pages: 16
DOI: 10.2174/138945008784911787
Price: $58

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