HCV and Autoimmunity

Author(s): S. Ferri, L. Muratori, M. Lenzi, A. Granito, F. B. Bianchi, D. Vergani.

Journal Name: Current Pharmaceutical Design

Volume 14 , Issue 17 , 2008

Abstract:

Hepatitis C virus (HCV) infection is characterized by a number of autoreactive manifestations, such as autoantibody production, cryoglobulinemia and thyroid disorders. We will analyse critically the mechanisms invoked, and partially documented, to explain such manifestations arising in genetically predisposed individuals exposed to HCV. In particular we will examine the available evidence implicating the virus in lowering the B cell activation threshold, in directly infecting lymphocytes and in inducing self-reactivity through a mechanism of molecular mimicry. We will then move to the HCV related clinical immunopathological manifestations, with a specific attention to the effects of antiviral treatment.

Keywords: Hepatitis C virus, immune system dysregulation, molecular mimicry, antiviral therapy

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Article Details

VOLUME: 14
ISSUE: 17
Year: 2008
Page: [1678 - 1685]
Pages: 8
DOI: 10.2174/138161208784746824
Price: $58

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