Current Gene Therapy

Ignacio Anegon
Director INSERM UMR 1064-Center for Research in Transplantation and Immunology
CHU de Nantes. 30, boulevard
Nantes
France

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Gene Therapy for Gastric Diseases

Author(s): Shintaro Fumoto, Junya Nishi, Junzo Nakamura, Koyo Nishida.

Abstract:

Gene therapy for gastric cancer and gastric ulcer is a rationalized strategy since various genes correlate with these diseases. Since gene expressions in non-target tissues/cells cause side effects, a selective gene delivery system targeted to the stomach and/or cancer must be developed. The route of vector transfer (direct injection, systemic, intraperitoneal, gastric serosal surface and oral administration) is an important issue which can determine efficacy and safety. Strategies for cancer gene therapy can be categorized as suicide gene therapy, growth inhibition and apoptosis induction, immunotherapy, anti-angiogenesis, and others. Combination of the target gene with other genes and/or strategies such as chemotherapy and virotherapy is promising. Candidates for treatment of gastric ulcer are vascular endothelial growth factor, angiopoietin-1, serum response factor, and cationic host defense peptide cathelicidin. In this review, we discuss stomachand cancer-targeted gene transfer methods and summarize gene therapy trials for gastric cancer and gastric ulcer.

Keywords: Gastric cancer, carcinoma, gastric ulcer, gene delivery, stomach

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Article Details

VOLUME: 8
ISSUE: 3
Year: 2008
Page: [187 - 200]
Pages: 14
DOI: 10.2174/156652308784746431
Price: $58