Current Drug Targets

Francis J. Castellino
Kleiderer-Pezold Professor of Biochemistry
Director, W.M. Keck Center for Transgene Research
Dean Emeritus, College of Science
230 Raclin-Carmichael Hall, University of Notre Dame
Notre Dame, IN 46556
USA

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Animal Models for Human Asthma: The Perspective of a Clinician

Author(s): Norbert Krug, Klaus F. Rabe.

Abstract:

The asthma animal model is still the only system that is available for modelling in vivo processes of human disease since for obvious ethical reasons these experiments are not possible in humans. However, there is a marked discrepancy between numerous successful studies in animals and very few rather disappointing clinical trials in patients. The current available models are usually uniform models of an acute asthmatic attack in adult animals, which do not spontaneously develop asthma. Major anatomical differences exist between human and animal airways and comparable lung function measurements are very difficult or impossible. The main reason why simplistic animal models may be inadequate lies probably in the diversity that exists within the different phenotypes of human asthma. Whereas progress is made to develop chronic asthma models with signs of airway remodelling, severe asthma and the role of small airways is still poorly reflected in current animal models.

Keywords: Animal model, asthma, severe asthma, small airways, airway remodelling

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Article Details

VOLUME: 9
ISSUE: 6
Year: 2008
Page: [438 - 442]
Pages: 5
DOI: 10.2174/138945008784533598
Price: $58