Cardiovascular & Hematological Disorders-Drug Targets

(Formerly Current Drug Targets - Cardiovascular & Hematological Disorders)

Garry X. Shen  
University of Manitoba
Winnipeg, MB
Canada

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Cardiac Role of the Transcription Factor NF-κB

Author(s): Salomon Hernandez Gutierrez, Manuel Ramos Kuri, Emilio Rojas del Castillo.

Abstract:

The signaling pathways that control the life-death switch of a cell are of primary interest in modern biology. In this respect, NF-??B has emerged as a decisive transcription factor in the cells response to apoptotic challenge and its effects on apoptosis have far-reaching consequences for normal development and/or homeostasis in many cells and tissues, including the immune system, hair follicles, and epidermal appendages, liver, nervous system and recently in heart . In this review we analyze the pivotal role of the transcription factor NF-κB in the normal functioning of the cardiac cell and its implication in common cardiac pathologies, such as ischemia-reperfusion injury, ischemic precondition, hypertrophy, atherosclerosis and cardiac arrest. While NF-κB is usually cytoprotective, it can also be pro-apoptotic depending on the inducing stimulus and the cellular context. Significant progress has been made in elucidating NF-κBs mode of action and its interplay with other key factors. These studies identified some anti- and pro-apoptotic NF-κB regulated genes that mediate its activity. These important new insights fuel hope that novel approaches will be developed to control the effects of NF-κB in cardiac pathologies.

Keywords: Heart, Cardiomyocytes, Apoptosis, Nuclear factor κB (NF-κB)

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Article Details

VOLUME: 8
ISSUE: 2
Year: 2008
Page: [153 - 160]
Pages: 8
DOI: 10.2174/187152908784533702
Price: $58