Current Cancer Therapy Reviews

Kurt S. Zaenker
Institute of Immunology and Experimental Oncology University Witten/Herdecke
Stockumerstraße 10, 58448 Witten
Germany

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Lymphocyte Biomarkers of Clinical Responses to Adoptive Immunotherapy of Malignant Melanoma

Author(s): Nathalie Labarriere, Brigitte Dreno, Francine Jotereau.

Abstract:

During the last few years, adoptive cellular therapy (ACT) — the isolation of antigen-specific lymphocytes, their ex vivo expansion and activation, and subsequent autologous administration — has been tested for treatment of melanoma tumours. Initial ACT used melanoma -infiltrating lymphocytes (TIL) that often contain tumour reactive lymphocytes, of diverse, mostly unknown, specificities [1, 2]. Recently, the identification of melanoma antigens [3] and the development of techniques for selection and expansion of epitope specific T cells has opened the way to the use of tumour antigen specific T cells, and importantly to immune follow up of ACT [4-9]. Despite these advances, several issues remain to address to achieve the major aims of ACT, as the rapid production of clinical grade T cells capable of eliciting a significant destruction of tumour tissue.

Keywords: lymphocyte, TCR transgenic T cells, melanoma infiltrating lymphocytes, tumour antigen, Peripheral Blood Mononuclear Cell

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Article Details

VOLUME: 4
ISSUE: 2
Year: 2008
Page: [125 - 129]
Pages: 5
DOI: 10.2174/157339408784310142
Price: $58