Abstract
A number of lectins that bind high-mannose carbohydrates on the surface of the envelopes of virus has been found to have antiviral activity. In particular, some algal lectins such as Cyanovirin-N, Microcystis viridis lectin, Scytovirin, Griffithsin and Oscillatoria agardhii agglutinin, exhibit high anti-HIV activity, and provide an alternative route to prevention of HIV transmission. This review focuses on the structural property, antiviral activity and possible mechanism of these lectins, and future challenges for potential prophylactic or therapeutic applications are also discussed.
Current Medicinal Chemistry
Title: Algal Lectins for Potential Prevention of HIV Transmission
Volume: 15 Issue: 11
Author(s): Yuqin Li, Xuewu Zhang, Gu Chen, Dong Wei and Feng Chen
Affiliation:
Keywords: Algae, lectin, anti-HIV, drug
Abstract: A number of lectins that bind high-mannose carbohydrates on the surface of the envelopes of virus has been found to have antiviral activity. In particular, some algal lectins such as Cyanovirin-N, Microcystis viridis lectin, Scytovirin, Griffithsin and Oscillatoria agardhii agglutinin, exhibit high anti-HIV activity, and provide an alternative route to prevention of HIV transmission. This review focuses on the structural property, antiviral activity and possible mechanism of these lectins, and future challenges for potential prophylactic or therapeutic applications are also discussed.
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Cite this article as:
Li Yuqin, Zhang Xuewu, Chen Gu, Wei Dong and Chen Feng, Algal Lectins for Potential Prevention of HIV Transmission, Current Medicinal Chemistry 2008; 15 (11) . https://dx.doi.org/10.2174/092986708784221421
DOI https://dx.doi.org/10.2174/092986708784221421 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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