Abstract
In the human body, mucosal surfaces of the intestinal tract are the largest and one of the most complex parts of the immune system. These surfaces are covered by a layer of epithelial cells which allows efficient absorption of nutrients but also serves to separate the intestine from an environment loaded with potential harmful agents. Discrimination between beneficial commensal bacteria, harmless antigens and pathogenic microorganisms is a central issue in the role that gut immune cells play in maintaining the balance between immune response and tolerance. However, the basis of this discrimination in the mucosal immune system, where this occurs and how it can affect both local and systemic responses is not yet well understood. Nevertheless, antigen uptake and presentation seems to be a crucial factor in this issue. In this review, we will discuss the key role of immune intestinal cells in the development of mucosal immunity, tolerance and disease.
Keywords: Peyers patches, Mesenteric Lymph Nodes, Intestinal Epithelial Cells, T cell tolerance, Dendritic Cells
Current Drug Targets
Title: Tolerance in Intestinal Inflammation and Cancer
Volume: 9 Issue: 5
Author(s): Marisa Vulcano, Silvio Danese and Antonio Sica
Affiliation:
Keywords: Peyers patches, Mesenteric Lymph Nodes, Intestinal Epithelial Cells, T cell tolerance, Dendritic Cells
Abstract: In the human body, mucosal surfaces of the intestinal tract are the largest and one of the most complex parts of the immune system. These surfaces are covered by a layer of epithelial cells which allows efficient absorption of nutrients but also serves to separate the intestine from an environment loaded with potential harmful agents. Discrimination between beneficial commensal bacteria, harmless antigens and pathogenic microorganisms is a central issue in the role that gut immune cells play in maintaining the balance between immune response and tolerance. However, the basis of this discrimination in the mucosal immune system, where this occurs and how it can affect both local and systemic responses is not yet well understood. Nevertheless, antigen uptake and presentation seems to be a crucial factor in this issue. In this review, we will discuss the key role of immune intestinal cells in the development of mucosal immunity, tolerance and disease.
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Cite this article as:
Vulcano Marisa, Danese Silvio and Sica Antonio, Tolerance in Intestinal Inflammation and Cancer, Current Drug Targets 2008; 9 (5) . https://dx.doi.org/10.2174/138945008784221143
DOI https://dx.doi.org/10.2174/138945008784221143 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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