Abstract
The sensory contact model can induce various different psychopathological states in male mice (anxious depression, catalepsy, social withdrawal, pathological aggression, cognition disturbances, anhedonia, alcoholism etc.). Additionally, this model facilitates the screening of drugs for therapeutic properties, preventive properties and efficiency under simulated clinical conditions. This approach can reveal the action of drugs at different stages of disease development. It is proposed that this pharmacological approach can be applied for the screening of various novel psychotropic drugs.
Keywords: Sensory contact model, psychotropic drugs, screening
Current Drug Metabolism
Title: An Experimental Approach for the Study of Psychotropic Drug Effects Under Simulated Clinical Conditions
Volume: 9 Issue: 4
Author(s): N. N. Kudryavtseva, D. F. Avgustinovich, N. P. Bondar, M. V. Tenditnik and I. L. Kovalenko
Affiliation:
Keywords: Sensory contact model, psychotropic drugs, screening
Abstract: The sensory contact model can induce various different psychopathological states in male mice (anxious depression, catalepsy, social withdrawal, pathological aggression, cognition disturbances, anhedonia, alcoholism etc.). Additionally, this model facilitates the screening of drugs for therapeutic properties, preventive properties and efficiency under simulated clinical conditions. This approach can reveal the action of drugs at different stages of disease development. It is proposed that this pharmacological approach can be applied for the screening of various novel psychotropic drugs.
Export Options
About this article
Cite this article as:
Kudryavtseva N. N., Avgustinovich F. D., Bondar P. N., Tenditnik V. M. and Kovalenko L. I., An Experimental Approach for the Study of Psychotropic Drug Effects Under Simulated Clinical Conditions, Current Drug Metabolism 2008; 9 (4) . https://dx.doi.org/10.2174/138920008784220592
DOI https://dx.doi.org/10.2174/138920008784220592 |
Print ISSN 1389-2002 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5453 |
Call for Papers in Thematic Issues
Interaction between drugs and endocrine diseases
The introduction of highly active antiretroviral therapy accelerated studies and our understanding on the interaction between pharmacological therapies and endocrine diseases. Drugs can precipitate endocrine via different mechanisms, including direct alteration of hormone production and secretion, dysregulation of hormonal axis, effects on hormonal transport, receptor-binding, and cellular signalling. Common drug-induced ...read more
Tissue Distribution and Metabolism of Micro- and Nanoparticles and Medical Implants
With the continuous advancement of modern science and engineering, numerous functional materials and active molecules have been developed and utilized in various industrial, medical, and food applications. Many of these can enter the body, either actively or passively, and have significant and intricate impacts on human health. For example, biomaterials ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
The Glucocorticoid Analog Dexamethasone Alters the Expression and the Distribution of Dopamine Receptors and Enkephalin within Cortico- Subcortical Regions
Current Molecular Pharmacology Chemical Research and Evaluation of the Antioxidant Activity of the Flowers of Annona coriacea Mart. (Annonaceae)
Current Bioactive Compounds The Role of Nitric Oxide Synthase Inhibitors in Schizophrenia
Current Medicinal Chemistry Passive Smoking, Endothelial Dysfunction and Related Markers in Healthy Individuals: An Update
Current Hypertension Reviews Synaptic Plasticity, Dementia and Alzheimer Disease
CNS & Neurological Disorders - Drug Targets Intravenous Immunoglobulins for Alzheimer's Disease
Current Alzheimer Research Acute Phenobarbital Poisoning for the Management of Seizures in Newborns and Children; A Systematic Literature Review
CNS & Neurological Disorders - Drug Targets Emerging Strategies to Strengthen the Anti-Tumour Activity of Type I Interferons: Overcoming Survival Pathways
Current Cancer Drug Targets Functional Roles of the Ca2+-activated K+ Channel, KCa3.1, in Brain Tumors
Current Neuropharmacology Serum Interleukin-33 is a Predictor of Depression in Patients with Acute Ischemic Stroke
Current Neurovascular Research Development of Arene Ruthenium Antitumor Complexes
Mini-Reviews in Medicinal Chemistry Study of Male Sex Hormone Levels in Male Egyptian Children with Beta-Thalassemia: Correlation with Iron load
Endocrine, Metabolic & Immune Disorders - Drug Targets Self-Regulatory Control and Habit Learning in the Development of Eating Disorders
Current Psychiatry Reviews Synchrotron Radiation in Life Sciences
Protein & Peptide Letters Genetically-Modified Human Pluripotent Stem Cells: New Hopes for the Understanding and the Treatment of Neurological Diseases?
Current Gene Therapy Corticotropin Releasing Factor (CRF) Peptide Family and their Receptors: Divergent Actions Influencing Human Physiology
Current Genomics Psychobiology of Eating Disorders – a Gateway to Precision Medicine
Current Neuropharmacology Computational Methods in Determination of Pharmacophore Models of 5-HT<sub>1A</sub>, 5-HT<sub>2A</sub> and 5-HT<sub>7</sub> Receptors
Mini-Reviews in Medicinal Chemistry Recent Development of CB2 Selective and Peripheral CB1/CB2 Cannabinoid Receptor Ligands
Current Medicinal Chemistry Polypharmacology of <i>Aconitum</i> and <i>Delphinium</i> sp. Diterpene Alka loids: Antiarrhythmic, Analgesic and Anti-Inflammatory Effects
Mini-Reviews in Organic Chemistry