Porphyrin-Carbohydrate Conjugates: Impact of Carbohydrate Moieties in Photodynamic Therapy (PDT)
Ravindra K. Pandey.
In recent years, a number or review articles describing the utility of porphyrin-based compounds in photodynamic therapy have been published.1 Currently, efforts are also underway in various laboratories to increase the tumor-specificity by developing targetspecific photosensitizers. One of such attempts has been to synthesize a series of carbohydrate-porphyrin conjugates and investigate their ability to target carbohydrate- recognized proteins, which are known for their high expression in certain tumors. The present article is focused on the synthesis and biological significance of carbohydrate conjugated photosensitizers.
Keywords: Photodynamic therapy, Photofrin®, Porphyrin, Carbohydrate-Porphyrin Conjugates
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