Abstract
“Epigenomics” can be termed as the study of the effects of chromatin structure, including the higher order of chromatin folding and attachment to the nuclear matrix, packaging of DNA around nucleosomes, covalent modifications of histone tails and DNA methylation. This has evolved to include any process that alters gene activity without changing the DNA sequence, and leads to modifications that can be transmitted to daughter cells. It also leads to a better knowledge of the changes in the regulation of genes and genomes that occur in major psychosis. It may also aid in understanding why the same gene sequence may predispose an individual to schizophrenia or bipolar disorder and in other cases does not, and elucidate the molecular mechanisms of how harmful; environmental factors interact with the genome. Results from the work may further lead to new diagnostics and effective therapies.
Keywords: Acetylation, epigenomics, metabolomics, sumolyation, microarray
Current Drug Metabolism
Title: Epigenomics
Volume: 9 Issue: 3
Author(s): Virendra S. Gomase and Somnath Tagore
Affiliation:
Keywords: Acetylation, epigenomics, metabolomics, sumolyation, microarray
Abstract: “Epigenomics” can be termed as the study of the effects of chromatin structure, including the higher order of chromatin folding and attachment to the nuclear matrix, packaging of DNA around nucleosomes, covalent modifications of histone tails and DNA methylation. This has evolved to include any process that alters gene activity without changing the DNA sequence, and leads to modifications that can be transmitted to daughter cells. It also leads to a better knowledge of the changes in the regulation of genes and genomes that occur in major psychosis. It may also aid in understanding why the same gene sequence may predispose an individual to schizophrenia or bipolar disorder and in other cases does not, and elucidate the molecular mechanisms of how harmful; environmental factors interact with the genome. Results from the work may further lead to new diagnostics and effective therapies.
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Cite this article as:
Gomase S. Virendra and Tagore Somnath, Epigenomics, Current Drug Metabolism 2008; 9 (3) . https://dx.doi.org/10.2174/138920008783884821
DOI https://dx.doi.org/10.2174/138920008783884821 |
Print ISSN 1389-2002 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5453 |
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