Current Cancer Drug Targets

Ruiwen Zhang 
Texas Tech University Health Sciences Center
1300 Coulter Drive
Amarillo, TX 79106
USA

Back

Natural and Synthetic Agents Targeting Inflammation and Angiogenesis for Chemoprevention of Prostate Cancer

Author(s): Spiridione Garbisa, Elena M.V. Araldi, Isabella Dell'Aica, Ilaria Sogno, Girieca Lorusso, Adriana Albini.

Abstract:

Prostate cancer is the most common cancer in men and one of the leading causes of cancer-related deaths in Western countries. The extraordinary biological heterogeneity, the increasing incidence of this disease, and the presence of putative premalignant conditions make prostate cancer a crucial pathology to study and test pharmacological or nutritional chemopreventive strategies. It has been demonstrated that the incidence of prostate cancer is lower in Asian people, and that it increases in Asian men living in Western countries; these data point to a pivotal role of diet in the onset of prostate cancer. A large amount of work has been done in investigating chemopreventive properties of dietary compounds widely used in Asian countries (i.e. soy, soybeans, green tea, fish) in respect of the oxidants- and meatrich diet typical of Western people, particularly of central and northern Europe. Some dietary products appear promising as chemopreventive agents for prostate cancer, because they display both anti-oxidant and anti-inflammatory activity – and inflammation is crucial for the aetiology of adeno-carcinoma of the prostate. There is increasing evidence for close correlation between inflammation, the microenvironment and tumour-associated neo-angiogenesis causing the adverse outcomes of prostate cancer. It may thus be useful to develop new strategies to couple the treatment of inflammation-related prostate cancer and the generation of angiopreventive or antiinflammatory molecules to prevent this disease. The search for compounds with few or no adverse effects – particularly cardiovascular – as compared with the agents currently in use is therefore of greatest relevance. This paper reviews the beneficial effects in this context of the most promising compounds: β-carotene, capsaicin, curcumin, daidzein, EGCG, genistein, hyperforin, lycopene, N-acetyl-L-cysteine, reductase inhibitors, resveratrol, selenium, silybinin, quercetin, vitamin-D and vitamin-E.

Keywords: Angiogenesis, Cancer, Chemoprevention, Prostate

Order Reprints Order Eprints Rights & PermissionsPrintExport

Article Details

VOLUME: 8
ISSUE: 2
Year: 2008
Page: [146 - 155]
Pages: 10
DOI: 10.2174/156800908783769382
Price: $58