Current Cancer Drug Targets

Ruiwen Zhang 
Texas Tech University Health Sciences Center
1300 Coulter Drive
Amarillo, TX 79106
USA

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Application of Proteome Analysis to the Assessment of Prognosis and Response Prediction in Clinical Oncology

Author(s): Christoph Rocken, Ralf Ketterlinus, Matthias P.A. Ebert.

Abstract:

In Europe more than 3 million individuals develop a malignancy annually. Despite recent progress in screening, diagnosis and therapy of most cancers, prognosis remains poor and only a minority of patients are cured. This owes to the fact that most cancers are diagnosed in advanced stages and due to the fact that treatment options for most cancers are limited. While there has been a substantial improvement in systemic therapy for many cancers it remains difficult to assess the potential responsiveness of the cancers towards these newly developed drugs, which include small molecules and monoclonal antibodies. Therefore various strategies have been developed in order to assess the prognosis and predict the expected tumor response in order to individualize the treatment, thereby offering the patient a tailored therapy which accounts for the tumor- and patient-specific morphological and molecular characteristics of the disease. This review summarizes recent efforts, challenges and limitations of proteome analysis in the assessment of prognosis and response-prediction in human cancers.

Keywords: Proteomics, translational oncology, prediction, prognosis, biomarker

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Article Details

VOLUME: 8
ISSUE: 2
Year: 2008
Page: [141 - 145]
Pages: 5
DOI: 10.2174/156800908783769328
Price: $58