Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

(Formerly Current Medicinal Chemistry - Anti-Inflammatory and Anti-Allergy Agents)

Bahar Tunctan
Department of Pharmacology
Faculty of Pharmacy
Mersin University
Mersin, 33169
Turkey

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Treatment of Allergic Rhinitis in Children

Author(s): Gurkan Kilic.

Abstract:

Allergic rhinitis is an inflammatory disease of nasal mucosa mediated by IgE-associated response to indoor and outdoor environmental allergens. The treatment of allergic rhinitis involves three main categories: avoidance of allergen, pharmacologic management and immunotherapy. The first therapeutic approach in allergic rhinitis is prevention, which is done by avoidance of causal allergens. This helps reduce the symptoms and the need for medications for allergic rhinitis. But allergen-avoidance measures should be considered before or in association with pharmacologic treatment. The intranasal steroids produce significant relief of all nasal symptoms of allergic rhinitis, including nasal congestion, sneezing, rhinorrhea, and itching. They are the first choice drugs in allergic rhinitis except mild intermittent rhinitis. In mild intermittent allergic rhinitis suggested initial treatment consists of an oral antihistaminic, an intranasal antihistaminic, and/or an oral or intranasal decongestant. Montelukast can be used in children as young as 6 months and it is approved by FDA for treatment of allergic rhinitis, in which it has shown clinical efficacy in both seasonal and perennial AR. Multiple randomized, double-blind, placebo controlled studies have shown efficacy of omalizumab (anti-IgE) in seasonal and perennial allergic rhinitis. However, the application of omalizumab in the treatment of allergic rhinitis in the absence of other atopic diseases will likely be restricted to a narrowly defined set of circumstances due to its cost. Specific immunotherapy should be considered when patients fail to respond to avoidance of allergens and pharmacotherapy or experience side effects, or when it is not cost effective.

Keywords: Allergic rhinitis, children, treatment, allergen avoidance, pharmacotherapy, immunotherapy

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Article Details

VOLUME: 7
ISSUE: 1
Year: 2008
Page: [38 - 44]
Pages: 7
DOI: 10.2174/187152308783769186