Apo A-1 Mimetic Peptides as Atheroprotective Agents in Murine Models

Author(s): Mohamad Navab, G. M. Anantharamaiah, Srinivasa T. Reddy, Brian J. Van Lenten, Alan M. Fogelman.

Journal Name: Current Drug Targets

Volume 9 , Issue 3 , 2008

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Abstract:

The mouse has proven to be an excellent model for testing apolipoprotein mimetic peptides as agents to treat a variety of vascular inflammatory conditions including atherosclerosis, cognitive dysfunction associated with arteriole inflammation, chronic rejection of transplanted hearts, and scleroderma. The mechanism of action appears to relate to the ability of these peptides to preferentially bind pro-inflammatory oxidized lipids and is independent of the chirality of the peptides since peptides synthesized from either D- or L-amino acids appear to be equally effective.

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Article Details

VOLUME: 9
ISSUE: 3
Year: 2008
Page: [204 - 209]
Pages: 6
DOI: 10.2174/138945008783755584
Price: $58

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