Current Drug Targets

Francis J. Castellino
Kleiderer-Pezold Professor of Biochemistry
Director, W.M. Keck Center for Transgene Research
Dean Emeritus, College of Science
230 Raclin-Carmichael Hall, University of Notre Dame
Notre Dame, IN 46556
USA

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Natural Antibodies in Murine Atherosclerosis

Author(s): Joseph L. Witztum, Christoph J. Binder, Meng-Yun Chou, Linda Fogelstrand, Karsten Hartvigsen, Peter X. Shaw and Agnes Boullier

Affiliation: University of Calif, San Diego,Basic Science Building-Room 1080, 9500 Gilman Drive, La Jolla, CA 92093, USA.

Abstract:

Natural antibodies are preformed antibodies that are present even in naive germ-free mice in the absence of any exogenous antigenic exposure. Consistent with their specificities for microbial antigens, natural antibodies play an important non-redundant role in the first line defense against bacterial and viral infections. On the other hand natural antibodies have also been shown to have specificities for self antigens, and therefore have been proposed to provide important homeostatic “house-keeping” functions. Many of the recognized self-antigens may in fact be stress-induced self-antigens, such as oxidation-specific epitopes that accumulate during atherogenesis as well as in many other inflammatory settings, and natural antibodies could protect from the impact of the pathological accumulation of these self-antigens. In this review we will discuss the specific example of the prototypic natural antibody T15/EO6, which is increased in atherosclerotic mice and mediates atheroprotection, and discuss the potential role of natural antibodies in atherogenesis in general.

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Article Details

VOLUME: 9
ISSUE: 3
Page: [190 - 195]
Pages: 6
DOI: 10.2174/138945008783755520
Price: $58