Synthesis, Properties and Application of Nucleic Acids Containing Phosphorothiolate Linkages

Author(s): Richard Cosstick , James W. Gaynor .

Journal Name: Current Organic Chemistry

Volume 12 , Issue 4 , 2008

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A largely historical survey is presented on the development of methods for the synthesis of oligonucleotides containing either 3??-S- or 5??-S-phosphorothiolate linkages. The properties of these modifications are discussed with emphasis on their specific cleavage and the use of a metal ion specificity switch for investigating the role of metal ions in enzyme- catalysed DNA/RNA cleavage processes. Finally, the effect of the 3??-S-phosphorothiolate modification on the structure of nucleic acids is described.

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Article Details

Year: 2008
Page: [291 - 308]
Pages: 18
DOI: 10.2174/138527208783743769
Price: $58

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PDF: 15