Chemical Strategies for Oligonucleotide-Conjugates Synthesis

Author(s): E. Defrancq , Y. Singh , N. Spinelli .

Journal Name: Current Organic Chemistry

Volume 12 , Issue 4 , 2008

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Abstract:

Oligonucleotide conjugates have found numerous applications in the field of diagnostics and therapeutics. Structurally diverse oligonucleotide conjugates have been prepared and evaluated for various applications. Research efforts have focused on the development of synthetic procedures to accomplish efficient oligonucleotide conjugation with different target molecules. Both on-support and solution-phase coupling procedures have been used to conjugate oligonucleotides. This review gives an account of major synthetic approaches available to prepare covalent oligonucleotide conjugates with diverse target molecules.

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Article Details

VOLUME: 12
ISSUE: 4
Year: 2008
Page: [263 - 290]
Pages: 28
DOI: 10.2174/138527208783743732
Price: $58

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