Abstract
Liver ischemia-reperfusion injury occurs in a number of clinical settings, including liver surgery, transplantation, and circulatory shock, leading to significant morbidity and mortality. There is a substantial evidence that hepatic ischemia-reperfusion injury results from an intense inflammatory response initiated by oxidative stress in the liver parenchyma during reperfusion. The anti-inflammatory effects of glucocorticosteroids (GCs) have been known for decades and have found extensive therapeutic use in a wide range of clinical situations associated with organ ischemia. Based on their biological effects, routine perioperative GCs administration has been advocated to reduce hepatic ischemic injury. However, the use of GCs in hepatic surgery remains controversial and clinical benefits are still uncertain. The aim of this review is to present the experimental and clinical evidence about the role of GCs in modulating hepatic ischemiareperfusion injury.
Keywords: Hepatic ischemia-reperfusion injury, liver surgery, surgical stress, glucocorticosteroids, steroids, glucocorticoids
Current Pharmaceutical Design
Title: The Protective Role of Steroids in Ischemia-Reperfusion Injury of the Liver
Volume: 14 Issue: 5
Author(s): Carlo Pulitano and Luca Aldrighetti
Affiliation:
Keywords: Hepatic ischemia-reperfusion injury, liver surgery, surgical stress, glucocorticosteroids, steroids, glucocorticoids
Abstract: Liver ischemia-reperfusion injury occurs in a number of clinical settings, including liver surgery, transplantation, and circulatory shock, leading to significant morbidity and mortality. There is a substantial evidence that hepatic ischemia-reperfusion injury results from an intense inflammatory response initiated by oxidative stress in the liver parenchyma during reperfusion. The anti-inflammatory effects of glucocorticosteroids (GCs) have been known for decades and have found extensive therapeutic use in a wide range of clinical situations associated with organ ischemia. Based on their biological effects, routine perioperative GCs administration has been advocated to reduce hepatic ischemic injury. However, the use of GCs in hepatic surgery remains controversial and clinical benefits are still uncertain. The aim of this review is to present the experimental and clinical evidence about the role of GCs in modulating hepatic ischemiareperfusion injury.
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Cite this article as:
Pulitano Carlo and Aldrighetti Luca, The Protective Role of Steroids in Ischemia-Reperfusion Injury of the Liver, Current Pharmaceutical Design 2008; 14 (5) . https://dx.doi.org/10.2174/138161208783597353
DOI https://dx.doi.org/10.2174/138161208783597353 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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