Abstract
Colloid science has now been reframed in advance form as nanotechnology. Novel nanoparticulate carrier systems could make an important impact on clinical practice, not only in the field of targeted drug delivery but also for the delivery of diagnostic agents, gene therapy and vaccine delivery as well. Polymer based nanoparticles are full of numerous advantages in delivery science but at the same time they suffer from toxicity considerations and problems in industrial scale up of the formulations. Lipid based carrier systems i.e. emulsions, liposomes etc. have been tried to solve such problems related to the delivery technology. Currently lipid-based nanoparticles gained much interest as they combine both the technology of lipid sciences and nanosciences, and hence may be better alternative carriers. Many aspects related to the development of solid lipid nanoparticles (SLNs) like production technology, effect of process parameters, selection of ingredients and route of delivery are important for the industrial applications of nanoscience. In the present review a detail discussion of methods of production of solid lipid nanoparticles, influence of ingredients of composition on product quality, therapeutic moiety effect, characterization parameters and effects of sterilization have been focused. Role of solid lipid nanoparticles for controlled and targeted drug delivery, utility as a novel transfection agent and their potential as adjuvant for vaccine delivery are summed up in addition. Clinical therapeutics of SLNs in terms of advantages and limitations of various routes of delivery of SLNs has also been explored for the further advancement of practical applications of solid lipid nanoparticles.
Call for Papers in Thematic Issues
Role of nanomaterials in fabrication of coatings, Machining and Joining
The application of nanoscience has brought about a revolution in the field of mechanical engineering by providing novel materials, boosting manufacturing processes, and generating cutting-edge products. The purpose of this special issue is to investigate the enormous impact that nanoscience has had on mechanical engineering, with a particular emphasis on ...read more
Advanced Inorganic Nanocomposites and Their Emerging Applications
This special issue collection will highlight developments on the recent trends about the synthesis of metal oxides, nanoclusters, biomaterials, 2D nanomaterials, nanocrystals, nanocomposites, etc. and their applications in electrochemical systems, tissue regeneration, energy storage and harvesting, sensors, etc. The novelty of the methods in the chemical synthesis and their characterizations, ...read more
Applicability of Nanotechnology for Performance Enhancement of Clean Energy Technologies
Population growth, industrialization, and improvement in living quality would lead to further increase in energy demand in near future. Regarding the disadvantages of fossil fuels such as fluctuations in their price, high emissions of greenhouse gases and restriction of their sources, it is crucial to use and exploit alternative energy ...read more
Graphene and 2D Materials for Energy Storage and Conversion
This thematic issue will discuss the recent advances in graphene-based nanomaterials for different energy technologies. Graphene possesses a high surface area, and stable structure and exhibits many interesting electronic, optical, and mechanical properties due to its 2D crystal structure. Graphene is of both fundamental interest and suitable for a wide ...read more
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