Current Cancer Therapy Reviews

Kurt S. Zaenker
Institute of Immunology and Experimental Oncology University Witten/Herdecke
Stockumerstraße 10, 58448 Witten
Germany

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Apoptosis Signaling Pathways in Anticancer Therapy

Author(s): Simone Fulda, Klaus-Michael Debatin.

Abstract:

One of the most important advances in cancer research in recent years is the recognition that killing of tumor cells by anticancer therapies commonly used in the treatment of cancer, e.g. chemotherapy, γ-irradiation, immunotherapy or suicide gene therapy, is predominantly mediated by triggering cell death pathways including apoptosis in cancer cells. Thus, failure to undergo apoptosis may result in treatment resistance of cancers. Understanding the molecular events that regulate apoptosis in response to anticancer therapy and how cancer cells evade apoptotic cell death, provides novel perspectives for a more rational approach to develop molecular targeted therapies for combating cancer.

Keywords: Apoptosis, cancer, cancer therapy, resistance

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Article Details

VOLUME: 4
ISSUE: 1
Year: 2008
Page: [14 - 20]
Pages: 7
DOI: 10.2174/157339408783565510